[Celiac disease]

Abstract

Celiac disease is an autoimmune disorder with a prevalence of approximately 1% in Europe, triggered by gluten ingestion in genetically predisposed individuals carrying HLA-DQ2 or HLA-DQ8 alleles. The clinical presentation ranges from asymptomatic cases to classic symptoms such as weight loss, bloating, and chronic diarrhea to extraintestinal manifestations affecting skin, bones, fertility, and mental health. The diagnosis is based on serological testing (anti-transglutaminase-IgA antibodies) and duodenal biopsies. The cornerstone of treatment remains a strict, lifelong gluten-free diet, which can normalize symptoms, reduce malignancy risk and mortality, improve fertility outcomes and possibly protect against other autoimmune diseases.

Neurotransmitters

None linked yet.

Related

• Celiac disease