Curcumin
Curcumin is the main polyphenol in turmeric, with anti-inflammatory and antioxidant activity. Small randomized trials suggest possible antidepressant, anti-anxiety, and osteoarthritis-pain benefits, but studies are small and heterogeneous, and curcumin’s poor absorption complicates interpretation. Evidence is preliminary and best regarded as promising rather than proven.
Too little may be associated with
Less anti-inflammatory and mood benefit.
Too much may be associated with
GI upset; blood-thinning interaction.
Informational only — not medical advice.
Research (5)
- Development and antibacterial evaluation of a dopamine-modified curcumin@zinc-based organic framework Qin et al. (2025)
- Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays Liu et al. (2024)
- Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review Liu et al. (2023)
- Nanowired Delivery of Curcumin Attenuates Methamphetamine Neurotoxicity and Elevates Levels of Dopamine and Brain-Derived Neurotrophic Factor Zhang et al. (2023)
- Antidepressant activity of curcumin: involvement of serotonin and dopamine system Kulkarni et al. (2008)
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