Folate
Folate (vitamin B9) is essential for DNA synthesis and one-carbon metabolism supporting neurotransmitter production. Correcting deficiency is important, and folate (especially L-methylfolate) shows modest benefit as an add-on in some people with depression. In folate-replete individuals, supplementation has not been shown to improve mood or prevent cognitive decline.
Too little may be associated with
Deficiency: low mood, anemia, neural-tube risk in pregnancy.
Too much may be associated with
High intake can mask B12 deficiency.
Informational only — not medical advice.
Neurotransmitters
Related
Research (11)
- Folate Deficiency-Induced Pseudo-Thrombotic Microangiopathy Allemand et al. (2026)
- Adjunctive Lumateperone in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial Durgam et al. (2025)
- Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling Rahman et al. (2025)
- Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies Ramaekers et al. (2022)
- Correction: Rossignol, D.A.; Frye, R.E. Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. J. Pers. Med. 2021, 11, 1141 Rossignol et al. (2022)
- The contribution of environmental exposure to the etiology of autism spectrum disorder Bölte et al. (2019)
- Cerebral folate deficiency Hyland et al. (2010)
- Cerebral folate deficiency Gordon (2009)
- Folate and depression--a neglected problem Young (2007)
- Folate deficiency Dinelli et al. (1999)
- Sepiapterin Reductase Deficiency Adam et al. (1993)
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